GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp7a1 | decreases expression | ISO | CYP7A1 (Homo sapiens) | 6480464 | CTD | Calcitriol results in decreased expression of CYP7A1 mRNA | PMID:20371703 | Cyp7a1 | multiple interactions | ISO | CYP7A1 (Homo sapiens) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol results in decreased expression of CYP7A1 mRNA]; [Calcitriol binds to and results in increased activity of VDR protein] promotes the reaction [VDR protein binds to CYP7A1 promoter]; [Calcitriol binds to and results in increased activity of VDR protein] which results in decreased expression of CYP7A1 mRNA; [Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] inhibits the reaction [PPARGC1A protein results in increased expression of CYP7A1 mRNA]; [Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] which results in decreased expression of CYP7A1 mRNA; Calcitriol inhibits the reaction [HNF4A protein binds to CYP7A1 mRNA]; Calcitriol inhibits the reaction [HNF4A protein binds to CYP7A1 promoter]; Calcitriol inhibits the reaction [NCOA2 protein binds to CYP7A1 mRNA]; Calcitriol inhibits the reaction [NCOA2 protein binds to CYP7A1 promoter]; Calcitriol inhibits the reaction [PPARGC1A protein binds to CYP7A1 mRNA]; Calcitriol inhibits the reaction [PPARGC1A protein binds to CYP7A1 promoter]; Calcitriol promotes the reaction [NCOR1 protein binds to CYP7A1 mRNA]; Calcitriol promotes the reaction [NCOR1 protein binds to CYP7A1 promoter]; Calcitriol promotes the reaction [NCOR2 protein binds to CYP7A1 mRNA]; Calcitriol promotes the reaction [NCOR2 protein binds to CYP7A1 promoter]; Calcitriol promotes the reaction [RXRA protein binds to CYP7A1 mRNA]; Calcitriol promotes the reaction [VDR protein binds to CYP7A1 mRNA]; CSK protein promotes the reaction [Calcitriol results in decreased expression of CYP7A1 mRNA]; NCOR1 protein promotes the reaction [[Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] inhibits the reaction [PPARGC1A protein results in increased expression of CYP7A1 mRNA]]; NCOR2 protein promotes the reaction [[Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] inhibits the reaction [PPARGC1A protein results in increased expression of CYP7A1 mRNA]]; Okadaic Acid promotes the reaction [Calcitriol results in decreased expression of CYP7A1 mRNA]; saracatinib inhibits the reaction [Calcitriol results in decreased expression of CYP7A1 mRNA]; U 0126 inhibits the reaction [Calcitriol inhibits the reaction [HNF4A protein binds to CYP7A1 mRNA]]; U 0126 inhibits the reaction [Calcitriol inhibits the reaction [PPARGC1A protein binds to CYP7A1 mRNA]]; U 0126 inhibits the reaction [Calcitriol promotes the reaction [NCOR1 protein binds to CYP7A1 mRNA]]; U 0126 inhibits the reaction [Calcitriol promotes the reaction [NCOR2 protein binds to CYP7A1 mRNA]]; U 0126 inhibits the reaction [Calcitriol promotes the reaction [RXRA protein binds to CYP7A1 mRNA]]; U 0126 inhibits the reaction [Calcitriol promotes the reaction [VDR protein binds to CYP7A1 mRNA]]; U 0126 inhibits the reaction [Calcitriol results in decreased expression of CYP7A1 mRNA] | PMID:19106115 PMID:20371703 | | ||||||||||||||||||||||
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