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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621628
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc22a12
Name: solute carrier family 22 member 12
Acc ID: CHEBI:17775
Term: 7,9-dihydro-1H-purine-2,6,8(3H)-trione
Definition: An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
Chemical ID: MESH:D014527
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc22a12affects transportEXP 6480464CTDSLC22A12 protein affects the transport of Uric AcidPMID:21074513
Slc22a12multiple interactionsEXP 6480464CTDBenzbromarone inhibits the reaction [SLC22A12 protein affects the transport of Uric Acid]; Chlorides affects the reaction [SLC22A12 protein affects the transport of Uric Acid]; Lactic Acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid]; pyrazinoic acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid]PMID:21074513
Slc22a12affects transportISOSlc22a12 (Mus musculus)6480464CTDSLC22A12 protein affects the transport of Uric AcidPMID:14747372
Slc22a12increases exportISOSlc22a12 (Mus musculus)6480464CTDSLC22A12 protein results in increased export of Uric AcidPMID:15284287
Slc22a12increases importISOSLC22A12 (Homo sapiens)6480464CTDSLC22A12 protein results in increased import of Uric AcidPMID:20639259
Slc22a12increases uptakeISOSLC22A12 (Homo sapiens)6480464CTDSLC22A12 protein results in increased uptake of Uric AcidPMID:14694169 PMID:21272127 PMID:21449597 PMID:33007874
Slc22a12multiple interactionsISOSLC22A12 (Homo sapiens)6480464CTD6-hydroxybenzbromarone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; [Chlorine co-treated with perfluoro-n-heptanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]; [Chlorine co-treated with perfluoro-n-nonanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]; [Chlorine co-treated with perfluorodecanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]; [Chlorine co-treated with perfluorooctanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]; [Losartan results in decreased activity of SLC22A12 protein] which results in decreased abundance of Uric Acid; benzarone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Benzbromarone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Chlorine inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]; E 3040 inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Enalapril inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Indomethacin inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Phenylbutazone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Probenecid inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Salicylates inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Sulfinpyrazone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Uric Acid inhibits the reaction [SLC22A12 protein results in increased uptake of Oxypurinol]PMID:16135657 PMID:18670416 PMID:20639259 PMID:21272127
Slc22a12multiple interactionsISOSlc22a12 (Mus musculus)6480464CTDBenzbromarone inhibits the reaction [SLC22A12 protein affects the transport of Uric Acid]; gluconic acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid]; Lactic Acid affects the reaction [SLC22A12 protein affects the transport of Uric Acid]; Probenecid inhibits the reaction [SLC22A12 protein affects the transport of Uric Acid]; pyrazinoic acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid]PMID:14747372
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