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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621769
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dhcr7
Name: 7-dehydrocholesterol reductase
Acc ID: CHEBI:17759
Term: cholesta-5,7-dien-3beta-ol
Definition: A 3beta-sterol that has formula C27H44O.
Chemical ID: MESH:C016705
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dhcr7increases abundanceISORGD:7317556480464CTDDHCR7 mutant form results in increased abundance of 7-dehydrocholesterolPMID:16446309
Dhcr7increases abundanceISORGD:7317566480464CTDDHCR7 mutant form results in increased abundance of 7-dehydrocholesterolPMID:16446309
Dhcr7increases reductionISORGD:7317556480464CTDDHCR7 results in increased reduction of 7-dehydrocholesterolPMID:15896653
Dhcr7multiple interactionsISORGD:7317556480464CTD[BM 15766 results in decreased activity of DHCR7 protein] which results in increased abundance of 7-dehydrocholesterolPMID:16365879 PMID:16824767
Dhcr7multiple interactionsISORGD:7317566480464CTDSimvastatin inhibits the reaction [DHCR7 mutant form results in increased abundance of 7-dehydrocholesterol]PMID:16446309
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