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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736925
Species: Homo sapiens
RGD Object: Gene
Symbol: GJA1
Name: gap junction protein alpha 1
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GJA1increases expressionEXP 6480464CTDDiethylhexyl Phthalate results in increased expression of GJA1 proteinPMID:31163220
GJA1affects expressionISOGja1 (Mus musculus)6480464CTDDiethylhexyl Phthalate affects the expression of GJA1 mRNAPMID:25351189
GJA1decreases expressionISOGja1 (Mus musculus)6480464CTDDiethylhexyl Phthalate results in decreased expression of GJA1 mRNAPMID:32619501
GJA1decreases expressionISOGja1 (Rattus norvegicus)6480464CTDDiethylhexyl Phthalate results in decreased expression of GJA1 proteinPMID:19344669 PMID:29940330
GJA1multiple interactionsISOGja1 (Rattus norvegicus)6480464CTD[Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of GJA1 protein]PMID:29940330
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