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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735985
Species: Mus musculus
RGD Object: Gene
Symbol: Acaa1a
Name: acetyl-Coenzyme A acyltransferase 1A
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acaa1adecreases expressionEXP 6480464CTDDiethylhexyl Phthalate results in decreased expression of ACAA1A mRNAPMID:35550907
Acaa1aincreases expressionEXP 6480464CTDDiethylhexyl Phthalate results in increased expression of ACAA1A mRNA; Diethylhexyl Phthalate results in increased expression of ACAA1A proteinPMID:16332691 PMID:19245819 PMID:19850644
Acaa1amultiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of ACAA1A mRNA; ATG7 protein inhibits the reaction [Diethylhexyl Phthalate results in increased expression of ACAA1A protein]; PPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of ACAA1A mRNA]PMID:16332691 PMID:19850644 PMID:28433925
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