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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735945
Species: Homo sapiens
RGD Object: Gene
Symbol: CPT1A
Name: carnitine palmitoyltransferase 1A
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CPT1Adecreases expressionISOCpt1a (Mus musculus)6480464CTDDiethylhexyl Phthalate results in decreased expression of CPT1A mRNAPMID:35550907 PMID:38199361
CPT1Aincreases expressionISOCpt1a (Mus musculus)6480464CTDDiethylhexyl Phthalate results in increased expression of CPT1A mRNA; Diethylhexyl Phthalate results in increased expression of CPT1A proteinPMID:19245819 PMID:20123618 PMID:37979351
CPT1Aincreases expressionISOCpt1a (Rattus norvegicus)6480464CTDDiethylhexyl Phthalate results in increased expression of CPT1A mRNAPMID:22672789
CPT1Amultiple interactionsISOCpt1a (Mus musculus)6480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diethyl phthalate co-treated with di-n-octyl phthalate co-treated with diisodecyl phthalate co-treated with diisononyl phthalate] results in decreased expression of CPT1A mRNA; [Dietary Fats co-treated with Diethylhexyl Phthalate] results in increased expression of CPT1A mRNA; [Ethanol co-treated with Diethylhexyl Phthalate] results in increased expression of CPT1A mRNA; [Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of CPT1A mRNA; GW 6471 inhibits the reaction [Diethylhexyl Phthalate results in increased expression of CPT1A protein]PMID:28433925 PMID:32325186 PMID:35739755 PMID:37979351 PMID:38199361
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