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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735823
Species: Homo sapiens
RGD Object: Gene
Symbol: GDNF
Name: glial cell derived neurotrophic factor
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GDNFincreases expressionEXP 6480464CTDDiethylhexyl Phthalate results in increased expression of GDNF mRNAPMID:31163220
GDNFdecreases expressionISOGdnf (Mus musculus)6480464CTDDiethylhexyl Phthalate results in decreased expression of GDNF mRNAPMID:35818324
GDNFdecreases expressionISOGdnf (Rattus norvegicus)6480464CTDDiethylhexyl Phthalate results in decreased expression of GDNF mRNAPMID:22677342
GDNFmultiple interactionsISOGdnf (Rattus norvegicus)6480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of GDNF promoter; [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GDNF mRNAPMID:23359474 PMID:25607892
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