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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735264
Species: Homo sapiens
RGD Object: Gene
Symbol: GSTM2
Name: glutathione S-transferase mu 2
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GSTM2decreases expressionISOGstm2 (Rattus norvegicus)6480464CTDDiethylhexyl Phthalate results in decreased expression of GSTM2 proteinPMID:8914623
GSTM2increases expressionISOGstm2 (Mus musculus)6480464CTDDiethylhexyl Phthalate results in increased expression of GSTM5 mRNAPMID:19850644
GSTM2multiple interactionsISOGstm2 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of GSTM2 mRNA; [Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of GSTM5 mRNA; PPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of GSTM5 mRNA]PMID:19850644 PMID:28433925
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