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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733892
Species: Mus musculus
RGD Object: Gene
Symbol: Gsk3b
Name: glycogen synthase kinase 3 beta
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsk3bincreases phosphorylationEXP 6480464CTDDiethylhexyl Phthalate results in increased phosphorylation of GSK3B proteinPMID:33484791
Gsk3bmultiple interactionsEXP 6480464CTDDiethylhexyl Phthalate promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased phosphorylation of GSK3B protein]PMID:33484791
Gsk3bdecreases phosphorylationISOGsk3b (Rattus norvegicus)6480464CTDDiethylhexyl Phthalate results in decreased phosphorylation of GSK3B proteinPMID:22610992 PMID:37364752
Gsk3bincreases phosphorylationISOGsk3b (Rattus norvegicus)6480464CTDDiethylhexyl Phthalate results in increased phosphorylation of GSK3B proteinPMID:29669060
Gsk3bincreases phosphorylationISOGSK3B (Homo sapiens)6480464CTDDiethylhexyl Phthalate results in increased phosphorylation of GSK3B proteinPMID:30944277
Gsk3bmultiple interactionsISOGsk3b (Rattus norvegicus)6480464CTDDiethylhexyl Phthalate inhibits the reaction [INS1 protein results in increased phosphorylation of GSK3B protein]; MK 2206 inhibits the reaction [Diethylhexyl Phthalate results in increased phosphorylation of GSK3B protein]PMID:28526321 PMID:29669060
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