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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732740
Species: Homo sapiens
RGD Object: Gene
Symbol: CAT
Name: catalase
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CATincreases activityEXP 6480464CTDDiethylhexyl Phthalate results in increased activity of CAT proteinPMID:31112013 PMID:35521929
CATmultiple interactionsEXP 6480464CTDcarvacrol inhibits the reaction [Diethylhexyl Phthalate results in increased activity of CAT protein]; Thymol inhibits the reaction [Diethylhexyl Phthalate results in increased activity of CAT protein]PMID:35521929
CATdecreases activityISOCat (Rattus norvegicus)6480464CTDDiethylhexyl Phthalate results in decreased activity of CAT proteinPMID:10528994 PMID:26854921 PMID:35970509
CATdecreases activityISOCat (Mus musculus)6480464CTDDiethylhexyl Phthalate results in decreased activity of CAT proteinPMID:35196152 PMID:35659966
CATdecreases expressionISOCat (Rattus norvegicus)6480464CTDDiethylhexyl Phthalate results in decreased expression of CAT mRNA; Diethylhexyl Phthalate results in decreased expression of CAT proteinPMID:32050098 PMID:36198370
CATincreases activityISOCat (Rattus norvegicus)6480464CTDDiethylhexyl Phthalate results in increased activity of CAT proteinPMID:2399535
CATincreases activityISOCat (Mus musculus)6480464CTDDiethylhexyl Phthalate results in increased activity of CAT proteinPMID:31486570
CATincreases expressionISOCat (Rattus norvegicus)6480464CTDDiethylhexyl Phthalate results in increased expression of CAT proteinPMID:2306265
CATincreases expressionISOCat (Mus musculus)6480464CTDDiethylhexyl Phthalate results in increased expression of CAT mRNA; Diethylhexyl Phthalate results in increased expression of CAT proteinPMID:35917956 PMID:36610486 PMID:36696656
CATmultiple interactionsISOCat (Rattus norvegicus)6480464CTDGrape Seed Extract inhibits the reaction [Diethylhexyl Phthalate results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CAT protein]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CAT mRNA]PMID:26854921 PMID:32050098 PMID:36198370
CATmultiple interactionsISOCat (Mus musculus)6480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in decreased expression of CAT mRNA; [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of CAT mRNA; Gallic Acid inhibits the reaction [Diethylhexyl Phthalate results in decreased activity of CAT protein]; Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of CAT mRNA]; Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of CAT protein]PMID:28013214 PMID:35196152 PMID:35917956 PMID:36610486 PMID:37364641
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