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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732222
Species: Mus musculus
RGD Object: Gene
Symbol: Gsr
Name: glutathione reductase
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsrdecreases expressionEXP 6480464CTDDiethylhexyl Phthalate results in decreased expression of GSR mRNAPMID:31211961
Gsrmultiple interactionsEXP 6480464CTD[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of GSR mRNAPMID:28013214
Gsrdecreases activityISOGsr (Rattus norvegicus)6480464CTDDiethylhexyl Phthalate results in decreased activity of GSR proteinPMID:26854921
Gsrmultiple interactionsISOGsr (Rattus norvegicus)6480464CTDGrape Seed Extract inhibits the reaction [Diethylhexyl Phthalate results in decreased activity of GSR protein]PMID:26854921
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