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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730847
Species: Mus musculus
RGD Object: Gene
Symbol: Casp8
Name: caspase 8
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp8decreases expressionEXP 6480464CTDDiethylhexyl Phthalate results in decreased expression of CASP8 mRNAPMID:31211961
Casp8increases expressionEXP 6480464CTDDiethylhexyl Phthalate results in increased expression of CASP8 mRNAPMID:25701202
Casp8multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diethyl phthalate co-treated with di-n-octyl phthalate co-treated with diisodecyl phthalate co-treated with diisononyl phthalate] results in increased expression of CASP8 protein; [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in increased expression of CASP8 protein; [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of CASP8 mRNAPMID:28013214 PMID:35739755 PMID:37364641
Casp8increases activityISOCASP8 (Homo sapiens)6480464CTDDiethylhexyl Phthalate results in increased activity of CASP8 proteinPMID:22155658
Casp8increases expressionISOCASP8 (Homo sapiens)6480464CTDDiethylhexyl Phthalate results in increased expression of CASP8 mRNAPMID:31163220
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