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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69106
Species: Mus musculus
RGD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i2increases activityEXP 6480464CTDDiethylhexyl Phthalate results in increased activity of NR1I2 proteinPMID:23899473
Nr1i2increases expressionEXP 6480464CTDDiethylhexyl Phthalate results in increased expression of NR1I2 mRNA; Diethylhexyl Phthalate results in increased expression of NR1I2 proteinPMID:17627975 PMID:36403809
Nr1i2multiple interactionsEXP 6480464CTDDiethylhexyl Phthalate binds to and results in increased activity of NR1I2 protein; Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of NR1I2 mRNA]; Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of NR1I2 protein]PMID:33049310 PMID:36403809
Nr1i2affects bindingISONR1I2 (Homo sapiens)6480464CTDDiethylhexyl Phthalate binds to NR1I2 proteinPMID:27071811 PMID:36893891
Nr1i2decreases expressionISONR1I2 (Homo sapiens)6480464CTDDiethylhexyl Phthalate results in decreased expression of NR1I2 mRNAPMID:31163220
Nr1i2increases activityISONr1i2 (Rattus norvegicus)6480464CTDDiethylhexyl Phthalate results in increased activity of NR1I2 proteinPMID:23899473
Nr1i2increases activityISONR1I2 (Homo sapiens)6480464CTDDiethylhexyl Phthalate results in increased activity of NR1I2 proteinPMID:22206814 PMID:23899473 PMID:27551952
Nr1i2multiple interactionsISONR1I2 (Homo sapiens)6480464CTDDiethylhexyl Phthalate binds to and results in increased activity of NR1I2 protein; Diethylhexyl Phthalate promotes the reaction [[NCOA1 protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]; Diethylhexyl Phthalate promotes the reaction [NR1I2 protein results in increased expression of ABCB1 mRNA]; Diethylhexyl Phthalate promotes the reaction [NR1I2 protein results in increased expression of CYP3A4]PMID:11581012 PMID:16054614 PMID:17003290 PMID:21227907 PMID:33049310 PMID:36893891
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