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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619981
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hdac6
Name: histone deacetylase 6
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hdac6multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Diethylnitrosamine] results in increased expression of HDAC6 mRNA; [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Diethylnitrosamine] results in increased expression of HDAC6 protein; [bisphenol A co-treated with Diethylhexyl Phthalate] results in increased expression of HDAC6 protein; [Diethylhexyl Phthalate co-treated with bisphenol A co-treated with Diethylnitrosamine co-treated with Methylnitrosourea co-treated with diisopropanolnitrosamine] results in increased expression of HDAC6 mRNA; [Diethylhexyl Phthalate co-treated with bisphenol A co-treated with Diethylnitrosamine co-treated with Methylnitrosourea co-treated with diisopropanolnitrosamine] results in increased expression of HDAC6 protein; [Diethylhexyl Phthalate co-treated with Diethylnitrosamine co-treated with Methylnitrosourea co-treated with diisopropanolnitrosamine] results in increased expression of HDAC6 mRNA; [Diethylhexyl Phthalate co-treated with Diethylnitrosamine co-treated with Methylnitrosourea co-treated with diisopropanolnitrosamine] results in increased expression of HDAC6 proteinPMID:34186418 PMID:34910997 PMID:36608567
Hdac6decreases expressionISOHDAC6 (Homo sapiens)6480464CTDDiethylhexyl Phthalate results in decreased expression of HDAC6 proteinPMID:31163220
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