GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3911
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tshr
Name: thyroid stimulating hormone receptor
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDDiethylhexyl Phthalate results in increased expression of TSHR protein

PMID:30543897
multiple interactionsISORGD:7370216480464CTDTSHR protein affects the reaction [Diethylhexyl Phthalate results in increased expression of CCNE1 protein]

TSHR protein affects the reaction [Diethylhexyl Phthalate results in increased expression of PAX8 protein]

TSHR protein affects the reaction [Diethylhexyl Phthalate results in increased phosphorylation of AKT1 protein]

TSHR protein affects the reaction [Diethylhexyl Phthalate results in increased phosphorylation of H2AFX protein]

TSHR protein affects the reaction [Diethylhexyl Phthalate results in increased phosphorylation of MAPK1 protein]

TSHR protein affects the reaction [Diethylhexyl Phthalate results in increased phosphorylation of MAPK3 protein]

PMID:30543897
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.