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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3705
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc2a2
Name: solute carrier family 2 member 2
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc2a2decreases expressionEXP 6480464CTDDiethylhexyl Phthalate results in decreased expression of SLC2A2 mRNA; Diethylhexyl Phthalate results in decreased expression of SLC2A2 proteinPMID:25280772 PMID:30597186
Slc2a2increases methylationEXP 6480464CTDDiethylhexyl Phthalate results in increased methylation of SLC2A2 promoterPMID:30597186
Slc2a2multiple interactionsEXP 6480464CTDDiethylhexyl Phthalate promotes the reaction [HNF1A protein binds to SLC2A2 promoter]; Diethylhexyl Phthalate promotes the reaction [SREBF1 protein binds to SLC2A2 promoter]PMID:30597186
Slc2a2decreases expressionISOSlc2a2 (Mus musculus)6480464CTDDiethylhexyl Phthalate results in decreased expression of SLC2A2 mRNAPMID:19245819 PMID:19850644 PMID:35457000
Slc2a2multiple interactionsISOSlc2a2 (Mus musculus)6480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diethyl phthalate co-treated with di-n-octyl phthalate co-treated with diisodecyl phthalate co-treated with diisononyl phthalate] results in increased expression of SLC2A2 mRNA; PPARA protein promotes the reaction [Diethylhexyl Phthalate results in decreased expression of SLC2A2 mRNA]PMID:19850644 PMID:35739755
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