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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDDiethylhexyl Phthalate results in increased expression of HMOX1 mRNA, Diethylhexyl Phthalate results in increased expression of HMOX1 protein

PMID:26361869, PMID:29663635, PMID:29940330
multiple interactionsEXP 6480464CTD[Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Diethylhexyl Phthalate results in increased expression of HMOX1 protein], Curcumin promotes the reaction [Diethylhexyl Phthalate results in increased expression of HMOX1 mRNA], Resveratrol promotes the reaction [Diethylhexyl Phthalate results in increased expression of HMOX1 mRNA]

PMID:26361869, PMID:29663635, PMID:29940330
decreases expressionISORGD:7309016480464CTDDiethylhexyl Phthalate results in decreased expression of HMOX1 mRNA, Diethylhexyl Phthalate results in decreased expression of HMOX1 protein

PMID:31112013
increases expressionISORGD:107176480464CTDDiethylhexyl Phthalate results in increased expression of HMOX1 mRNA

PMID:24646702
multiple interactionsISORGD:107176480464CTD[Diethylhexyl Phthalate results in increased expression of HMOX1 mRNA] which results in increased activity of CASP3 protein, [OVAL protein results in increased susceptibility to Diethylhexyl Phthalate] which results in increased expression of HMOX1 mRNA

PMID:23148021, PMID:24646702
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.