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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDDiethylhexyl Phthalate results in increased expression of BAX mRNA; Diethylhexyl Phthalate results in increased expression of BAX proteinPMID:32050098 PMID:37979351
Baxmultiple interactionsEXP 6480464CTDHesperidin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of BAX protein]PMID:32050098
Baxincreases expressionISOBax (Mus musculus)6480464CTDDiethylhexyl Phthalate results in increased expression of BAX mRNA; Diethylhexyl Phthalate results in increased expression of BAX proteinPMID:24458533 PMID:25701202 PMID:26678702 PMID:33484791 PMID:35659966 PMID:38008054
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDDiethylhexyl Phthalate results in increased expression of BAX mRNA; Diethylhexyl Phthalate results in increased expression of BAX proteinPMID:22155658 PMID:31163220
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD[diethyl phthalate co-treated with Dibutyl Phthalate co-treated with diisobutyl phthalate co-treated with Diethylhexyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisononyl phthalate] results in increased expression of BAX mRNA; [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of BAX mRNA; Diethylhexyl Phthalate promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of BAX protein]; Melatonin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of BAX protein]PMID:28013214 PMID:33484791 PMID:37021957 PMID:38008054
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD2-chloro-5-nitrobenzanilide inhibits the reaction [Diethylhexyl Phthalate results in increased expression of BAX protein]PMID:31163220
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