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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2087
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aldh1a1
Name: aldehyde dehydrogenase 1 family, member A1
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aldh1a1increases expressionEXP 6480464CTDDiethylhexyl Phthalate results in increased expression of ALDH1A1 mRNAPMID:22584684
Aldh1a1decreases expressionISOALDH1A1 (Homo sapiens)6480464CTDDiethylhexyl Phthalate results in decreased expression of ALDH1A1 mRNAPMID:31163220
Aldh1a1increases expressionISOAldh1a1 (Mus musculus)6480464CTDDiethylhexyl Phthalate results in increased expression of ALDH1A1 mRNAPMID:17998271 PMID:19245819
Aldh1a1increases expressionISOALDH1A1 (Homo sapiens)6480464CTDDiethylhexyl Phthalate results in increased expression of ALDH1A1 proteinPMID:31163220
Aldh1a1multiple interactionsISOAldh1a1 (Mus musculus)6480464CTD[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in increased expression of ALDH1A1 mRNAPMID:30768133
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