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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2018
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acly
Name: ATP citrate lyase
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aclyincreases expressionISOAcly (Mus musculus)6480464CTDDiethylhexyl Phthalate results in increased expression of ACLY mRNAPMID:19850644 PMID:35550907
Aclymultiple interactionsISOAcly (Mus musculus)6480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diethyl phthalate co-treated with di-n-octyl phthalate co-treated with diisodecyl phthalate co-treated with diisononyl phthalate] results in increased expression of ACLY mRNA; [Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ACLY mRNA; PPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of ACLY mRNA]PMID:19850644 PMID:28433925 PMID:35739755
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