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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1558311
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp2b10
Name: cytochrome P450, family 2, subfamily b, polypeptide 10
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2b10increases expressionEXP 6480464CTDDiethylhexyl Phthalate results in increased expression of CYP2B10 mRNAPMID:17627975 PMID:19245819 PMID:19850644 PMID:26519955
Cyp2b10multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] affects the expression of CYP2B10 mRNA; [Dietary Fats co-treated with Dietary Sucrose] affects the reaction [[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] affects the expression of CYP2B10 mRNA]; PPARA protein inhibits the reaction [Diethylhexyl Phthalate results in increased expression of CYP2B10 mRNA]PMID:19850644 PMID:30722647
Cyp2b10decreases expressionISOCYP2B6 (Homo sapiens)6480464CTDDiethylhexyl Phthalate results in decreased expression of CYP2B6 mRNAPMID:31163220
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