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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1317889
Species: Mus musculus
RGD Object: Gene
Symbol: Akr1c12
Name: aldo-keto reductase family 1, member C12
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akr1c12increases expressionEXP 6480464CTDDiethylhexyl Phthalate results in increased expression of AKR1C12 mRNA

PMID:19850644, PMID:25975992
Akr1c12multiple interactionsEXP 6480464CTDPPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of AKR1C12 mRNA]

PMID:19850644
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.