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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ncoa1
Name: nuclear receptor coactivator 1
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ncoa1multiple interactionsISONCOA1 (Homo sapiens)6480464CTDDiethylhexyl Phthalate promotes the reaction [[NCOA1 protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]PMID:11581012
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