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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305324
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Spry4
Name: sprouty RTK signaling antagonist 4
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Spry4decreases expressionISOSpry4 (Mus musculus)6480464CTDDiethylhexyl Phthalate results in decreased expression of SPRY4 mRNAPMID:19850644
Spry4increases expressionISOSPRY4 (Homo sapiens)6480464CTDDiethylhexyl Phthalate results in increased expression of SPRY4 mRNAPMID:31163220
Spry4multiple interactionsISOSpry4 (Mus musculus)6480464CTDPPARA protein promotes the reaction [Diethylhexyl Phthalate results in decreased expression of SPRY4 mRNA]PMID:19850644
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