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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10742
Species: Mus musculus
RGD Object: Gene
Symbol: Hspa5
Name: heat shock protein 5
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspa5decreases expressionEXP 6480464CTDDiethylhexyl Phthalate results in decreased expression of HSPA5 mRNAPMID:21318169
Hspa5multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in increased expression of HSPA5 mRNA; [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in increased expression of HSPA5 proteinPMID:37364641
Hspa5decreases expressionISOHspa5 (Rattus norvegicus)6480464CTDDiethylhexyl Phthalate results in decreased expression of HSPA5 proteinPMID:16400681
Hspa5increases expressionISOHspa5 (Rattus norvegicus)6480464CTDDiethylhexyl Phthalate results in increased expression of GRP78 protein; Diethylhexyl Phthalate results in increased expression of HSPA5 mRNAPMID:21318169 PMID:25280772 PMID:37979351
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