GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hmox1 | decreases expression | ISO | HMOX1 (Homo sapiens) | 6480464 | CTD | bardoxolone methyl results in decreased expression of HMOX1 mRNA | PMID:35724838 | Hmox1 | increases expression | ISO | Hmox1 (Mus musculus) | 6480464 | CTD | bardoxolone methyl results in increased expression of HMOX1 mRNA; bardoxolone methyl results in increased expression of HMOX1 protein | PMID:21289052 PMID:24530882 | Hmox1 | increases expression | ISO | HMOX1 (Homo sapiens) | 6480464 | CTD | bardoxolone methyl results in increased expression of HMOX1 mRNA; bardoxolone methyl results in increased expression of HMOX1 protein | PMID:25246272 PMID:28790194 PMID:34480604 PMID:35724838 | Hmox1 | multiple interactions | ISO | Hmox1 (Mus musculus) | 6480464 | CTD | [bardoxolone methyl co-treated with aristolochic acid I] results in increased expression of HMOX1 mRNA; bardoxolone methyl promotes the reaction [aristolochic acid I results in increased expression of HMOX1 protein] | PMID:24530882 | Hmox1 | multiple interactions | ISO | HMOX1 (Homo sapiens) | 6480464 | CTD | bardoxolone methyl inhibits the reaction [eriodictyol results in decreased expression of HMOX1 protein]; GSK3B protein mutant form inhibits the reaction [bardoxolone methyl results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [bardoxolone methyl results in increased expression of HMOX1 protein] | PMID:25246272 PMID:28790194 PMID:37020356 | | ||||||||||||||||||||||
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