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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68497
Species: Homo sapiens
RGD Object: Gene
Symbol: DHODH
Name: dihydroorotate dehydrogenase (quinone)
Acc ID: CHEBI:177387
Term: brequinar
Definition: A quinolinemonocarboxylic acid that is quinoline substituted by 2'-fluoro[1,1'-biphenyl]-4-yl, methyl, carboxy and fluoro groups at positions 2, 3, 4, and 6, respectively. It is an inhibitor of dihydroorotate dehydrogenase, an enzyme that is required for de novo pyrimidine biosynthesis. The compound exhibits antineoplastic and antiviral properties.
Chemical ID: MESH:C046943
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
DHODHdecreases activityEXP 6480464CTDbrequinar results in decreased activity of DHODH proteinPMID:10658902 PMID:9802339
DHODHdecreases activityISODhodh (Rattus norvegicus)6480464CTDbrequinar results in decreased activity of DHODH proteinPMID:10658902 PMID:9776318 PMID:9802339
DHODHmultiple interactionsISODhodh (Rattus norvegicus)6480464CTDbrequinar inhibits the reaction [DHODH protein results in increased metabolism of 4,5-dihydroorotic acid]; brequinar inhibits the reaction [DHODH protein results in increased metabolism of Quinones]; brequinar inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]PMID:9776318 PMID:9802339
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