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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737014
Species: Mus musculus
RGD Object: Gene
Symbol: Tlr4
Name: toll-like receptor 4
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tlr4multiple interactionsISOTlr4 (Rattus norvegicus)6480464CTDNicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TLR4 mRNA]PMID:27984197
Tlr4multiple interactionsISOTLR4 (Homo sapiens)6480464CTD[Aerosols co-treated with Nicotine] results in increased expression of TLR4 mRNAPMID:33469865
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