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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735741
Species: Homo sapiens
RGD Object: Gene
Symbol: TIMP3
Name: TIMP metallopeptidase inhibitor 3
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TIMP3affects expressionEXP 6480464CTDNicotine affects the expression of TIMP3 mRNAPMID:18986645
TIMP3multiple interactionsEXP 6480464CTD[Nicotine co-treated with lipopolysaccharide, E. coli O26-B6] affects the expression of TIMP3 mRNAPMID:18986645
TIMP3multiple interactionsISOTimp3 (Mus musculus)6480464CTD[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TIMP3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TIMP3 mRNA]PMID:20230807
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