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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730848
Species: Homo sapiens
RGD Object: Gene
Symbol: EDN1
Name: endothelin 1
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EDN1increases expressionISOEdn1 (Mus musculus)6480464CTDNicotine results in increased expression of EDN1 mRNA; Nicotine results in increased expression of EDN1 proteinPMID:33082140
EDN1multiple interactionsISOEdn1 (Mus musculus)6480464CTDMIR98 mRNA inhibits the reaction [Nicotine results in increased expression of EDN1 mRNA]; NGF protein affects the reaction [Nicotine results in increased expression of EDN1 mRNA]; Rosiglitazone inhibits the reaction [Nicotine results in increased expression of EDN1 mRNA]PMID:33082140
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