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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69423
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Srebf1increases expressionEXP 6480464CTDNicotine results in increased expression of SREBF1 mRNAPMID:29155039
Srebf1multiple interactionsEXP 6480464CTD[Nicotine results in increased abundance of Cotinine] which results in increased expression of SREBF1 mRNAPMID:29617909
Srebf1decreases expressionISOSREBF1 (Homo sapiens)6480464CTDNicotine results in decreased expression of SREBF1 mRNAPMID:18247414
Srebf1increases expressionISOSrebf1 (Mus musculus)6480464CTDNicotine results in increased expression of SREBF1 mRNAPMID:31622651
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