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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68350
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr5a1
Name: nuclear receptor subfamily 5, group A, member 1
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDNicotine results in decreased expression of NR5A1 mRNA, Nicotine results in decreased expression of NR5A1 protein

PMID:24709674, PMID:28986172
decreases expressionISORGD:684936480464CTDNicotine results in decreased expression of NR5A1 mRNA, Nicotine results in decreased expression of NR5A1 protein

PMID:24709674
multiple interactionsISORGD:684936480464CTDtrichostatin A inhibits the reaction [Nicotine results in decreased expression of NR5A1 mRNA]

PMID:24709674
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.