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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61909
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1h3
Name: nuclear receptor subfamily 1, group H, member 3
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1h3decreases expressionEXP 6480464CTDNicotine results in decreased expression of NR1H3 mRNA; Nicotine results in decreased expression of NR1H3 proteinPMID:30036686
Nr1h3multiple interactionsEXP 6480464CTDNicotine promotes the reaction [NR1H3 protein binds to FASN promoter]; Nicotine results in increased expression of and results in increased activity of NR1H3 proteinPMID:24368177
Nr1h3decreases expressionISONR1H3 (Homo sapiens)6480464CTDNicotine results in decreased expression of NR1H3 mRNA; Nicotine results in decreased expression of NR1H3 proteinPMID:30036686
Nr1h3multiple interactionsISONR1H3 (Homo sapiens)6480464CTDVecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H3 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H3 protein]PMID:30036686
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