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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionEXP 6480464CTDNicotine results in decreased expression of BCL2 mRNA; Nicotine results in decreased expression of BCL2 proteinPMID:20339300 PMID:29972271
Bcl2increases expressionEXP 6480464CTDNicotine results in increased expression of BCL2 proteinPMID:34153408
Bcl2multiple interactionsEXP 6480464CTDFolic Acid inhibits the reaction [Nicotine results in decreased expression of BCL2 protein]PMID:29972271
Bcl2decreases expressionISOBcl2 (Mus musculus)6480464CTDNicotine results in decreased expression of BCL2 mRNAPMID:15831280 PMID:30896085
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDNicotine results in decreased expression of BCL2 proteinPMID:33010382
Bcl2increases expressionISOBcl2 (Mus musculus)6480464CTDNicotine results in increased expression of BCL2 proteinPMID:31783125
Bcl2increases expressionISOBCL2 (Homo sapiens)6480464CTDNicotine results in increased expression of BCL2 mRNA; Nicotine results in increased expression of BCL2 protein; Nicotine results in increased expression of BCL2 protein modified formPMID:18448488 PMID:18676776 PMID:20061081 PMID:20727180 PMID:30076938 PMID:30836163
Bcl2increases phosphorylationISOBCL2 (Homo sapiens)6480464CTDNicotine results in increased phosphorylation of BCL2 proteinPMID:12421819
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTDroyal jelly inhibits the reaction [Nicotine results in decreased expression of BCL2 mRNA]PMID:30896085
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD3-methyladenine inhibits the reaction [Nicotine results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of BCL2 protein]; edelfosine inhibits the reaction [Nicotine results in increased phosphorylation of BCL2 protein]; EIF4E protein affects the reaction [Nicotine results in increased expression of BCL2 protein]; MK-886 inhibits the reaction [Nicotine results in increased expression of BCL2 protein]; Nicotine inhibits the reaction [Aflatoxin B1 results in decreased expression of BCL2 protein]PMID:12421819 PMID:20061081 PMID:20727180 PMID:22743290 PMID:30836163 PMID:33010382
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