GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bax | affects localization | EXP | | 6480464 | CTD | Nicotine affects the localization of BAX protein | PMID:18203686 | Bax | decreases expression | EXP | | 6480464 | CTD | Nicotine results in decreased expression of BAX protein | PMID:34153408 | Bax | increases expression | EXP | | 6480464 | CTD | Nicotine results in increased expression of BAX mRNA; Nicotine results in increased expression of BAX protein | PMID:20339300 PMID:29972271 | Bax | multiple interactions | EXP | | 6480464 | CTD | Folic Acid inhibits the reaction [Nicotine results in increased expression of BAX protein] | PMID:29972271 | Bax | decreases expression | ISO | Bax (Mus musculus) | 6480464 | CTD | Nicotine results in decreased expression of BAX mRNA; Nicotine results in decreased expression of BAX protein | PMID:17135361 PMID:31783125 | Bax | decreases expression | ISO | BAX (Homo sapiens) | 6480464 | CTD | Nicotine results in decreased expression of BAX protein | PMID:20061081 PMID:20106947 PMID:30259641 | Bax | increases expression | ISO | Bax (Mus musculus) | 6480464 | CTD | Nicotine results in increased expression of BAX mRNA | PMID:15831280 | Bax | increases expression | ISO | BAX (Homo sapiens) | 6480464 | CTD | Nicotine results in increased expression of BAX protein | PMID:33010382 | Bax | increases phosphorylation | ISO | BAX (Homo sapiens) | 6480464 | CTD | Nicotine results in increased phosphorylation of BAX protein | PMID:17525161 | Bax | multiple interactions | ISO | BAX (Homo sapiens) | 6480464 | CTD | 3-methyladenine inhibits the reaction [Nicotine results in increased expression of BAX protein]; [Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in decreased expression of BAX protein; MK-886 inhibits the reaction [Nicotine results in decreased expression of BAX protein]; Nicotine inhibits the reaction [[Cisplatin co-treated with Etoposide] affects the localization of BAX protein]; PRKCZ protein affects the reaction [Nicotine results in increased phosphorylation of BAX protein] | PMID:17525161 PMID:18676776 PMID:20061081 PMID:30259641 PMID:33010382 | |
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