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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1602133
Species: Homo sapiens
RGD Object: Gene
Symbol: UBA2
Name: ubiquitin like modifier activating enzyme 2
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
UBA2increases expressionEXP 6480464CTDNicotine results in increased expression of UBA2 proteinPMID:21554491
UBA2multiple interactionsEXP 6480464CTD[Nicotine results in increased expression of UBA2 protein] which results in increased sumoylation of EEF2 proteinPMID:21554491
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