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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1598663
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Elk1
Name: ETS transcription factor ELK1
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Elk1increases phosphorylationEXP 6480464CTDNicotine results in increased phosphorylation of ELK1 proteinPMID:29486207
Elk1increases phosphorylationISOELK1 (Homo sapiens)6480464CTDNicotine results in increased phosphorylation of ELK1 proteinPMID:29486207
Elk1multiple interactionsISOELK1 (Homo sapiens)6480464CTDVecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of ELK1 protein]PMID:29486207
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