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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1593939
Species: Rattus norvegicus
RGD Object: Gene
Symbol: E2f2
Name: E2F transcription factor 2
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:13489826480464CTDNicotine promotes the reaction [E2F2 protein binds to CDC25A promoter], Nicotine promotes the reaction [E2F2 protein binds to CDC6 promoter]

PMID:16862215
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