GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | RELA | affects localization | EXP | | 6480464 | CTD | Nicotine affects the localization of RELA protein | PMID:34171359 | RELA | increases expression | EXP | | 6480464 | CTD | Nicotine results in increased expression of RELA protein | PMID:34171359 | RELA | increases phosphorylation | EXP | | 6480464 | CTD | Nicotine results in increased phosphorylation of RELA protein | PMID:34890707 | RELA | multiple interactions | EXP | | 6480464 | CTD | [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide co-treated with U 0126] inhibits the reaction [Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of RELA protein]; Acetylcysteine inhibits the reaction [Nicotine results in increased phosphorylation of RELA protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]]; Nicotine affects the localization of and results in increased activity of RELA protein; Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]; U 0126 inhibits the reaction [Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]] | PMID:16254210 PMID:18448488 PMID:34171359 PMID:34890707 | RELA | decreases expression | ISO | Rela (Mus musculus) | 6480464 | CTD | Nicotine results in decreased expression of RELA mRNA; Nicotine results in decreased expression of RELA protein | PMID:17135361 | RELA | multiple interactions | ISO | Rela (Mus musculus) | 6480464 | CTD | 2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [Nicotine results in decreased expression of RELA protein]; Nicotine affects the localization of and results in increased activity of RELA protein | PMID:16254210 PMID:17135361 | RELA | multiple interactions | ISO | Rela (Rattus norvegicus) | 6480464 | CTD | Mecamylamine analog inhibits the reaction [Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [RELA protein binds to NFKB1 protein]]]; methyllycaconitine analog inhibits the reaction [Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [RELA protein binds to NFKB1 protein]]]; Nicotine inhibits the reaction [Acetic Acid results in increased expression of RELA protein]; Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [RELA protein binds to NFKB1 protein]] | PMID:23810507 PMID:27984197 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |