GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | TNF | increases degradation | EXP | | 6480464 | CTD | Nicotine results in increased degradation of TNF mRNA | PMID:21606497 | TNF | increases secretion | EXP | | 6480464 | CTD | Nicotine results in increased secretion of TNF protein | PMID:29673796 | TNF | multiple interactions | EXP | | 6480464 | CTD | [Lipopolysaccharides co-treated with Nicotine] results in increased expression of TNF mRNA; [Lipopolysaccharides co-treated with Nicotine] results in increased secretion of TNF protein; Bungarotoxins inhibits the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF mRNA]]; methyllycaconitine inhibits the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF mRNA]]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Nicotine promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of TNF mRNA]; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased secretion of TNF protein]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of TNF mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased secretion of TNF protein]; ZFP36 mRNA affects the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; ZFP36 mRNA affects the reaction [Nicotine results in increased degradation of TNF mRNA] | PMID:21606497 PMID:23199342 PMID:29673796 | TNF | affects expression | ISO | Tnf (Rattus norvegicus) | 6480464 | CTD | Nicotine affects the expression of TNF mRNA | PMID:32512034 | TNF | decreases expression | ISO | Tnf (Mus musculus) | 6480464 | CTD | Nicotine results in decreased expression of TNF protein | PMID:25396421 | TNF | decreases expression | ISO | Tnf (Rattus norvegicus) | 6480464 | CTD | Nicotine results in decreased expression of TNF mRNA | PMID:15135227 | TNF | increases expression | ISO | Tnf (Mus musculus) | 6480464 | CTD | Nicotine results in increased expression of TNF mRNA; Nicotine results in increased expression of TNF protein | PMID:16254210 PMID:21237301 | TNF | increases expression | ISO | Tnf (Rattus norvegicus) | 6480464 | CTD | Nicotine results in increased expression of TNF mRNA; Nicotine results in increased expression of TNF protein | PMID:17216608 PMID:20426880 | TNF | increases secretion | ISO | Tnf (Mus musculus) | 6480464 | CTD | Nicotine results in increased secretion of TNF protein | PMID:21237301 | TNF | multiple interactions | ISO | Tnf (Mus musculus) | 6480464 | CTD | Acetylcysteine inhibits the reaction [Nicotine results in increased expression of TNF mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased secretion of TNF protein]; Eugenol inhibits the reaction [Nicotine results in increased expression of TNF mRNA]; Eugenol inhibits the reaction [Nicotine results in increased secretion of TNF protein]; HMOX1 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Nicotine inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; Nicotine inhibits the reaction [IFNG protein results in increased expression of TNF mRNA]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; STAT3 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; ZFP36 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; ZFP36 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; zinc protoporphyrin inhibits the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]] | PMID:21237301 PMID:24095726 PMID:31926917 | TNF | multiple interactions | ISO | Tnf (Rattus norvegicus) | 6480464 | CTD | [Nicotine results in increased abundance of Cotinine] which results in increased expression of TNF mRNA; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of TNF protein]; erdosteine inhibits the reaction [Nicotine results in increased expression of TNF protein]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of TNF mRNA]; Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; Vitamin E inhibits the reaction [Nicotine results in increased expression of TNF protein] | PMID:15135227 PMID:17216608 PMID:27984197 PMID:29617909 | | ||||||||||||||||||||||
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