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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10615
Species: Mus musculus
RGD Object: Gene
Symbol: Gad1
Name: glutamate decarboxylase 1
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gad1decreases methylationISOGad1 (Rattus norvegicus)6480464CTDNicotine results in decreased methylation of GAD1 promoterPMID:28555334
Gad1increases expressionISOGad1 (Rattus norvegicus)6480464CTDNicotine results in increased expression of GAD1 mRNA; Nicotine results in increased expression of GAD1 proteinPMID:18312583 PMID:28555334
Gad1multiple interactionsISOGad1 (Rattus norvegicus)6480464CTDDihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in increased expression of GAD1 mRNA]PMID:28555334
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