Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	70835
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	CYP11B1
Name:	cytochrome P450 family 11 subfamily B member 1

Acc ID:	CHEBI:17650
Term:	cortisol
Definition:	A 17alpha-hydroxy-C21-steroid that is pregn-4-ene substituted by oxo groups at positions 3 and 20 and hydroxy groups at positions 11, 17 and 21. Cortisol is a corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex, which is a part of the adrenal gland. It is usually referred to as the 'stress hormone' as it is involved in response to stress and anxiety, controlled by corticotropin-releasing hormone (CRH). It increases blood pressure and blood sugar, and reduces immune responses.
Chemical ID:	MESH:D006854

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
CYP11B1	affects metabolic processing	EXP		6480464	CTD	CYP11B1 protein affects the metabolism of Hydrocortisone	PMID:16030167
CYP11B1	increases chemical synthesis	EXP		6480464	CTD	CYP11B1 protein results in increased chemical synthesis of Hydrocortisone	PMID:16054388 PMID:19900470
CYP11B1	multiple interactions	EXP		6480464	CTD	3',4'-dimethoxyflavone promotes the reaction [CYP11B1 protein results in increased chemical synthesis of Hydrocortisone]; alpha-naphthoflavone promotes the reaction [CYP11B1 protein results in increased chemical synthesis of Hydrocortisone]; beta-Naphthoflavone promotes the reaction [CYP11B1 protein results in increased chemical synthesis of Hydrocortisone]	PMID:22172629

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