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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69423
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:17650
Term: cortisol
Definition: A 17alpha-hydroxy-C21-steroid that is pregn-4-ene substituted by oxo groups at positions 3 and 20 and hydroxy groups at positions 11, 17 and 21. Cortisol is a corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex, which is a part of the adrenal gland. It is usually referred to as the 'stress hormone' as it is involved in response to stress and anxiety, controlled by corticotropin-releasing hormone (CRH). It increases blood pressure and blood sugar, and reduces immune responses
Chemical ID: MESH:D006854
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:694736480464CTDHydrocortisone results in increased expression of SREBF1 mRNA

PMID:30776459
multiple interactionsISORGD:694736480464CTDCEBPA protein affects the reaction [Hydrocortisone results in increased expression of SREBF1 mRNA], NR3C1 protein affects the reaction [Hydrocortisone results in increased expression of SREBF1 mRNA], Resveratrol inhibits the reaction [Hydrocortisone results in increased expression of SREBF1 mRNA]

PMID:30776459
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.