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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 14209199
Species: Sus scrofa
RGD Object: Gene
Symbol: POMC
Name: proopiomelanocortin
Acc ID: CHEBI:17650
Term: cortisol
Definition: A 17alpha-hydroxy-C21-steroid that is pregn-4-ene substituted by oxo groups at positions 3 and 20 and hydroxy groups at positions 11, 17 and 21. Cortisol is a corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex, which is a part of the adrenal gland. It is usually referred to as the 'stress hormone' as it is involved in response to stress and anxiety, controlled by corticotropin-releasing hormone (CRH). It increases blood pressure and blood sugar, and reduces immune responses
Chemical ID: MESH:D006854
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
POMCincreases abundanceEXP 6480464CTDPOMC protein alternative form results in increased abundance of Hydrocortisone

PMID:1666317
POMCincreases secretionEXP 6480464CTDPOMC protein results in increased secretion of Hydrocortisone

PMID:21466817 PMID:22100847
POMCmultiple interactionsEXP 6480464CTDDitiocarb promotes the reaction [Sodium Selenite inhibits the reaction [POMC protein results in increased secretion of Hydrocortisone]] Sodium Selenite inhibits the reaction [POMC protein results in increased secretion of Hydrocortisone]

PMID:21466817
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