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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10696
Species: Mus musculus
RGD Object: Gene
Symbol: Gsta2
Name: glutathione S-transferase, alpha 2 (Yc2)
Acc ID: CHEBI:17650
Term: cortisol
Definition: A 17alpha-hydroxy-C21-steroid that is pregn-4-ene substituted by oxo groups at positions 3 and 20 and hydroxy groups at positions 11, 17 and 21. Cortisol is a corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex, which is a part of the adrenal gland. It is usually referred to as the 'stress hormone' as it is involved in response to stress and anxiety, controlled by corticotropin-releasing hormone (CRH). It increases blood pressure and blood sugar, and reduces immune responses.
Chemical ID: MESH:D006854
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsta2decreases expressionISOGsta2 (Rattus norvegicus)6480464CTDHydrocortisone results in decreased expression of GSTA2 mRNAPMID:10476907
Gsta2increases expressionISOGsta2 (Rattus norvegicus)6480464CTDHydrocortisone results in increased expression of GSTA2 mRNAPMID:11502894
Gsta2multiple interactionsISOGsta2 (Rattus norvegicus)6480464CTDHydrocortisone inhibits the reaction [sulforaphane results in increased expression of GSTA2 mRNA]PMID:22606287
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