Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736627
Species: Homo sapiens
RGD Object: Gene
Symbol: FN1
Name: fibronectin 1
Acc ID: CHEBI:17634
Term: D-glucose
Definition: A glucose with D-configuration.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FN1decreases expressionEXP 6480464CTDGlucose results in decreased expression of FN1 mRNAPMID:31655124
FN1decreases secretionEXP 6480464CTDGlucose deficiency results in decreased secretion of FN1 proteinPMID:24802182
FN1increases expressionEXP 6480464CTDGlucose results in increased expression of FN1 mRNA; Glucose results in increased expression of FN1 proteinPMID:12388107 PMID:15086456 PMID:17199790 PMID:22228707 PMID:26045780 PMID:29163160 PMID:31494106
FN1increases secretionEXP 6480464CTDGlucose results in increased secretion of FN1 proteinPMID:16320596 PMID:21829520
FN1multiple interactionsEXP 6480464CTD3-aminobenzamide inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; 4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid inhibits the reaction [Glucose results in increased expression of FN1 protein]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Glucose results in increased secretion of FN1 protein]; [Glucose results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased secretion of FN1 protein; acetovanillone inhibits the reaction [Glucose results in increased secretion of FN1 protein]; AKT activator SC79 inhibits the reaction [FOXP1 protein inhibits the reaction [Glucose results in increased expression of and results in increased secretion of FN1 protein]]; alpha-Tocopherol inhibits the reaction [Glucose results in increased expression of and results in increased secretion of FN1 protein]; Bosentan inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; Bosentan inhibits the reaction [Glucose results in increased expression of FN1 protein]; BQ 788 inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; calphostin C inhibits the reaction [Glucose results in increased secretion of FN1 protein]; chelerythrine inhibits the reaction [Glucose results in increased expression of FN1 protein]; Curcumin inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of FN1 protein]; diphenyleneiodonium inhibits the reaction [Glucose results in increased secretion of FN1 protein]; DKK1 protein inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; ERCC1 protein affects the reaction [Glucose results in increased expression of FN1 mRNA]; ERCC4 protein affects the reaction [Glucose results in increased expression of FN1 mRNA]; FOXP1 protein inhibits the reaction [Glucose results in increased expression of and results in increased secretion of FN1 protein]; FOXP1 protein inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; gingerol inhibits the reaction [Glucose results in increased secretion of FN1 protein]; Glucose results in increased expression of and results in increased secretion of FN1 protein; Indomethacin inhibits the reaction [Glucose results in increased secretion of FN1 protein]; MAPK14 protein promotes the reaction [Glucose results in increased secretion of FN1 protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Glucose results in increased expression of FN1 protein]; Rotenone inhibits the reaction [Glucose results in increased secretion of FN1 protein]; sitaxsentan inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; SN50 peptide inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; SN50 peptide inhibits the reaction [Glucose results in increased expression of FN1 protein]; trichostatin A inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; Troglitazone inhibits the reaction [Glucose results in increased expression of FN1 mRNA]PMID:12388107 PMID:15086456 PMID:16320596 PMID:17199790 PMID:21829520 PMID:22228707 PMID:26045780 PMID:29163160 PMID:31494106 PMID:9225831
FN1decreases expressionISOFn1 (Mus musculus)6480464CTDGlucose results in decreased expression of FN1 proteinPMID:17178593
FN1decreases expressionISOFn1 (Rattus norvegicus)6480464CTDGlucose results in decreased expression of FN1 proteinPMID:17178593
FN1increases expressionISOFn1 (Mus musculus)6480464CTDGlucose results in increased expression of FN1 mRNA; Glucose results in increased expression of FN1 proteinPMID:14520012 PMID:19765649 PMID:33270355
FN1increases expressionISOFn1 (Rattus norvegicus)6480464CTDGlucose results in increased expression of FN1 mRNA; Glucose results in increased expression of FN1 proteinPMID:16572112 PMID:20060012 PMID:21998146 PMID:22245600 PMID:23376009 PMID:26891083 PMID:29031534 PMID:31838053
FN1multiple interactionsISOFn1 (Mus musculus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SMARCA4A protein inhibits the reaction [Glucose results in increased expression of FN1 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SMARCA4A protein inhibits the reaction [Glucose results in increased expression of FN1 protein]]; Enalaprilat inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; NFE2L2 protein affects the reaction [SMARCA4A protein inhibits the reaction [Glucose results in increased expression of FN1 mRNA]]; Resveratrol inhibits the reaction [Glucose results in increased expression of FN1 protein]; SMARCA4A protein inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; SMARCA4A protein inhibits the reaction [Glucose results in increased expression of FN1 protein]; TXNIP promotes the reaction [Glucose results in increased expression of FN1 mRNA]PMID:14520012 PMID:17178593 PMID:19765649 PMID:33270355
FN1multiple interactionsISOFn1 (Rattus norvegicus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; [[[Glucose results in increased expression of CYBA protein] co-treated with [Glucose results in increased expression of NCF1 protein]] results in increased chemical synthesis of Reactive Oxygen Species] which results in increased expression of FN1 protein; [Glucose results in increased chemical synthesis of Reactive Oxygen Species] which results in increased expression of FN1; [JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; [sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein; acetovanillone inhibits the reaction [Glucose results in increased expression of FN1 protein]; Acetylcysteine inhibits the reaction [Glucose results in increased expression of FN1 protein]; cinnamaldehyde inhibits the reaction [Glucose results in increased expression of FN1 protein]; CYBA protein promotes the reaction [Glucose results in increased expression of FN1 protein]; diphenyleneiodonium inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; diphenyliodonium inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; farrerol inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; farrerol inhibits the reaction [Glucose results in increased expression of FN1 protein]; HIF1A protein affects the reaction [Glucose results in increased expression of FN1 protein]; LY2109761 inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; manumycin inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; MIR217 mRNA affects the reaction [Glucose results in increased expression of FN1 protein]; N,N-dimethylsphingosine inhibits the reaction [Glucose results in increased expression of FN1 protein]; NCF1 protein promotes the reaction [Glucose results in increased expression of FN1 protein]; Resveratrol inhibits the reaction [[[[Glucose results in increased expression of CYBA protein] co-treated with [Glucose results in increased expression of NCF1 protein]] results in increased chemical synthesis of Reactive Oxygen Species] which results in increased expression of FN1 protein]; Resveratrol inhibits the reaction [Glucose results in increased expression of FN1 protein]; rhodioloside inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; SB 203580 inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; SIRT1 protein affects the reaction [Resveratrol inhibits the reaction [Glucose results in increased expression of FN1 protein]]; SPHK1 mRNA affects the reaction [Glucose results in increased expression of FN1 protein]; SPHK1 protein inhibits the reaction [Glucose results in increased expression of FN1 protein]; Superoxides affects the reaction [Glucose results in increased expression of FN1 mRNA]; TXNIP protein affects the reaction [Glucose results in increased expression of FN1 mRNA]; TXNIP protein affects the reaction [Glucose results in increased expression of FN1 protein]; Y 27632 inhibits the reaction [Glucose results in increased expression of FN1 protein]PMID:16572112 PMID:20060012 PMID:21998146 PMID:22245600 PMID:22406263 PMID:23376009 PMID:26891083 PMID:29031534 PMID:31838053
Go Back to source page   Continue to Ontology report