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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730901
Species: Homo sapiens
RGD Object: Gene
Symbol: HMOX1
Name: heme oxygenase 1
Acc ID: CHEBI:17634
Term: D-glucose
Definition: A glucose with D-configuration.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HMOX1affects expressionEXP 6480464CTDGlucose affects the expression of HMOX1 proteinPMID:32942007
HMOX1decreases activityEXP 6480464CTDGlucose results in decreased activity of HMOX1 promoterPMID:14766238
HMOX1decreases expressionEXP 6480464CTDGlucose results in decreased expression of HMOX1 mRNA; Glucose results in decreased expression of HMOX1 proteinPMID:21333731 PMID:32602595 PMID:37586544
HMOX1increases expressionEXP 6480464CTDGlucose deficiency results in increased expression of HMOX1 mRNA; Glucose results in increased expression of HMOX1 proteinPMID:21333731 PMID:23954465 PMID:29649567
HMOX1multiple interactionsEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in decreased expression of HMOX1 protein]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Rosiglitazone inhibits the reaction [Glucose results in decreased expression of HMOX1 protein]]; 4-Nitroquinoline-1-oxide inhibits the reaction [Glucose results in decreased expression of HMOX1 protein]; [4-Nitroquinoline-1-oxide results in increased susceptibility to Glucose] which results in increased expression of HMOX1 protein; [Oxygen co-treated with Glucose] promotes the reaction [Vehicle Emissions promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of HMOX1 protein]]; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of HMOX1 protein; Berberine promotes the reaction [Glucose results in increased expression of HMOX1 protein]; Glucose inhibits the reaction [4-Nitroquinoline-1-oxide affects the expression of HMOX1 protein]; Glucose promotes the reaction [cobaltiprotoporphyrin results in increased expression of HMOX1 mRNA]; Glucose promotes the reaction [tin mesoporphyrin results in increased expression of HMOX1 mRNA]; Particulate Matter promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of HMOX1 protein]; Rosiglitazone inhibits the reaction [Glucose results in decreased expression of HMOX1 protein]; solanesol inhibits the reaction [Glucose results in decreased expression of HMOX1 mRNA]; solanesol inhibits the reaction [Glucose results in decreased expression of HMOX1 protein]; spiraeoside inhibits the reaction [Glucose results in decreased expression of HMOX1 protein]; Vehicle Emissions promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of HMOX1 protein]PMID:19924377 PMID:21333731 PMID:23954465 PMID:28400208 PMID:32602595 PMID:32942007 PMID:37586544
HMOX1affects expressionISOHmox1 (Rattus norvegicus)6480464CTDGlucose affects the expression of HMOX1 mRNAPMID:22643931
HMOX1decreases expressionISOHmox1 (Rattus norvegicus)6480464CTDGlucose results in decreased expression of HMOX1 mRNA; Glucose results in decreased expression of HMOX1 proteinPMID:23770986
HMOX1increases expressionISOHmox1 (Mus musculus)6480464CTDGlucose results in increased expression of HMOX1 mRNA; Glucose results in increased expression of HMOX1 proteinPMID:19489000 PMID:33270355
HMOX1increases expressionISOHmox1 (Rattus norvegicus)6480464CTDGlucose results in increased expression of HMOX1PMID:16464909
HMOX1multiple interactionsISOHmox1 (Mus musculus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SMARCA4A protein promotes the reaction [Glucose results in increased expression of HMOX1 protein]]; [lard co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of HMOX1 mRNA; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of HMOX1 mRNA; Antioxidants inhibits the reaction [Glucose results in increased expression of HMOX1 mRNA]; Glucose deficiency promotes the reaction [Simvastatin results in increased expression of HMOX1 mRNA]; Glucose deficiency promotes the reaction [Simvastatin results in increased expression of HMOX1 protein]; MIR144 mRNA inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of HMOX1 mRNA]; NFE2L2 mutant form inhibits the reaction [Glucose deficiency promotes the reaction [Simvastatin results in increased expression of HMOX1 mRNA]]; SMARCA4A protein promotes the reaction [Glucose results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Glucose deficiency promotes the reaction [Simvastatin results in increased expression of HMOX1 protein]]PMID:17928392 PMID:19489000 PMID:29457851 PMID:33270355 PMID:37567420
HMOX1multiple interactionsISOHmox1 (Rattus norvegicus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[diallyl trisulfide co-treated with Glucose] results in increased expression of HMOX1 protein]; [cobaltiprotoporphyrin results in increased expression of HMOX1 protein] which results in decreased susceptibility to Glucose; [diallyl trisulfide co-treated with Glucose] results in increased expression of HMOX1 protein; [Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of HMOX1 mRNA; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of HMOX1 mRNA; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of HMOX1 protein; Acetylcysteine affects the reaction [Glucose affects the expression of HMOX1 mRNA]; Antioxidants inhibits the reaction [Glucose results in increased expression of HMOX1]; cobaltiprotoporphyrin inhibits the reaction [Glucose results in decreased activity of HMOX1 protein]; cobaltiprotoporphyrin promotes the reaction [Glucose results in increased expression of HMOX1 protein]; diosmetin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of HMOX1 mRNA]; diosmetin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of HMOX1 protein]; Glucose results in decreased activity of and results in increased expression of HMOX1 protein; GSK3B protein inhibits the reaction [MIR135A mRNA inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of HMOX1 mRNA]]; HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in decreased phosphorylation of STAT3 protein]]; HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]]; HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of ACTA1 mRNA]]; HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of NPPA mRNA]]; HMOX1 protein promotes the reaction [diallyl trisulfide inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CASP3 protein modified form]]; manganese(III)-tetrakis(4-benzoic acid)porphyrin affects the reaction [Glucose affects the expression of HMOX1 mRNA]; MIR135A mRNA inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of HMOX1 mRNA]; Propofol inhibits the reaction [Glucose results in decreased activity of HMOX1 protein]; Propofol promotes the reaction [Glucose results in increased expression of HMOX1 protein]; Quercetin inhibits the reaction [Glucose results in decreased expression of HMOX1 mRNA]; Quercetin inhibits the reaction [Glucose results in decreased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Glucose results in decreased activity of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin promotes the reaction [Glucose results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Propofol inhibits the reaction [Glucose results in decreased activity of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Propofol promotes the reaction [Glucose results in increased expression of HMOX1 protein]]PMID:16464909 PMID:22111038 PMID:22643931 PMID:23453443 PMID:23770986 PMID:24810525 PMID:25896937 PMID:29719095 PMID:35191607
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