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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62109
Species: Mus musculus
RGD Object: Gene
Symbol: Col1a1
Name: collagen, type I, alpha 1
Acc ID: CHEBI:17634
Term: D-glucose
Definition: A glucose with D-configuration.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Col1a1affects secretionISOCOL1A1 (Homo sapiens)6480464CTDGlucose deficiency affects the secretion of COL1A1 proteinPMID:24802182
Col1a1decreases expressionISOCOL1A1 (Homo sapiens)6480464CTDGlucose results in decreased expression of COL1A1 mRNAPMID:38000455
Col1a1increases expressionISOCol1a1 (Rattus norvegicus)6480464CTDGlucose results in increased expression of COL1A1 mRNAPMID:28700904
Col1a1increases expressionISOCOL1A1 (Homo sapiens)6480464CTDGlucose results in increased expression of COL1A1 mRNAPMID:29163160
Col1a1multiple interactionsISOCol1a1 (Rattus norvegicus)6480464CTDCurcumin analog inhibits the reaction [Glucose results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of COL1A1 mRNA]PMID:28700904
Col1a1multiple interactionsISOCOL1A1 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytic Acid inhibits the reaction [Glucose results in decreased expression of COL1A1 mRNA]]; DKK1 protein inhibits the reaction [Glucose results in increased expression of COL1A1 mRNA]; Melatonin inhibits the reaction [Glucose results in decreased expression of COL1A1 mRNA]; Phytic Acid inhibits the reaction [Glucose results in decreased expression of COL1A1 mRNA]PMID:29163160 PMID:38000455
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