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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1604438
Species: Homo sapiens
RGD Object: Gene
Symbol: MAFA
Name: MAF bZIP transcription factor A
Acc ID: CHEBI:17634
Term: D-glucose
Definition: A glucose with D-configuration.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAFAmultiple interactionsEXP 6480464CTD3,4-dihydro-5-methyl-1(2H)-isoquinolinone inhibits the reaction [Glucose inhibits the reaction [MAFA protein binds to INS promoter]]; 3-aminobenzamide inhibits the reaction [Glucose inhibits the reaction [MAFA protein binds to INS promoter]]; Niacinamide inhibits the reaction [Glucose inhibits the reaction [MAFA protein binds to INS promoter]]PMID:16505238
MAFAaffects expressionISOMafa (Rattus norvegicus)6480464CTDGlucose affects the expression of MAFA mRNAPMID:24349266
MAFAincreases expressionISOMafa (Mus musculus)6480464CTDGlucose results in increased expression of MAFA mRNAPMID:22558381
MAFAincreases expressionISOMafa (Rattus norvegicus)6480464CTDGlucose results in increased expression of MAFA mRNAPMID:22558381
MAFAmultiple interactionsISOMafa (Mus musculus)6480464CTDIL1B protein inhibits the reaction [Glucose results in increased expression of MAFA mRNA]; lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [Glucose results in increased expression of MAFA mRNA]; Palmitic Acid inhibits the reaction [Glucose results in increased expression of MAFA mRNA]; TLR4 affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [Glucose results in increased expression of MAFA mRNA]]PMID:22558381
MAFAmultiple interactionsISOMafa (Rattus norvegicus)6480464CTD3,4-dihydro-5-methyl-1(2H)-isoquinolinone inhibits the reaction [Glucose results in decreased expression of MAFA mRNA]; 3,4-dihydro-5-methyl-1(2H)-isoquinolinone inhibits the reaction [Glucose results in decreased expression of MAFA protein]; 3-aminobenzamide inhibits the reaction [Glucose results in decreased expression of MAFA mRNA]; 3-aminobenzamide inhibits the reaction [Glucose results in decreased expression of MAFA protein]; lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [Glucose results in increased expression of MAFA mRNA]PMID:16505238 PMID:22558381
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