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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:17634
Term: D-glucose
Definition: A glucose with D-configuration.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1decreases expressionISOESR1 (Homo sapiens)6480464CTDGlucose results in decreased expression of ESR1 mRNAPMID:16621514
Esr1increases abundanceISOESR1 (Homo sapiens)6480464CTDESR1 protein results in increased abundance of GlucosePMID:31520823
Esr1increases expressionISOESR1 (Homo sapiens)6480464CTDGlucose results in increased expression of ESR1 mRNAPMID:16621514
Esr1increases phosphorylationISOESR1 (Homo sapiens)6480464CTDGlucose results in increased phosphorylation of ESR1 proteinPMID:23690508
Esr1multiple interactionsISOEsr1 (Rattus norvegicus)6480464CTD[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of ESR1 mRNA; ESR1 protein promotes the reaction [[Resveratrol results in increased localization of SLC2A4 protein] which results in increased uptake of Glucose]; tetrahydropalmatine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of ESR1 mRNA]PMID:18426865 PMID:37606869
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDEndosulfan promotes the reaction [ESR1 protein results in increased abundance of Glucose]PMID:31520823
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